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KMID : 0371019960290010043
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Journal of Preventive Medicine and Public Health
1996 Volume.29 No. 1 p.43 ~ p.50
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Nephropathy in Chronic Lead Poisoning
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Kim Byoung-Gwon
Kim Sung-Ryul
Hong Young-Seoub
Rha Seo-Hee
Kim Jung-Man
Jung Kap-Yeol
Kim Joon-Youn
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Abstract
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We experienced a case of nephropathy in chronic lead poisoning. The patient was 43-year-old male who has been working in secondarq lead smelting plant for 14 years. On admission, blood pressure was 160/90 mmHg and the others were non-specific. In past history, he received chelating agent administration for lead poisoning irregularly and medicated for gout, and the blood lead concentration was 180.0 pgldl on 2 months before admission. Smoking habit has been 1 pack per day for 15 years and drinking habit has been 1 bottle of Soju per day but less now.
In liver function test, AST/ALT were 27/28 IU/l and rGT was 456 IU/l. In blood test, Hb : 11. 5 gldl, Hct : 34.0% and basophilic stipplings were found in peripheral blood smear. Chest PA was normal and abdominal ultrasonographic finding was non-specific except fatty liver. In the test of lead exposure indices, PbB : 83.0 ggldl, PbU : 28.3 ugl l , and blood ZPP was 300.0 ugldl. And in renal function test, BUN : 31.4 mg/dl, blood creatinine : 2.7 mg/dl, blood uric acid : 9.1 mgldl, urinary albumin : 100.0 mglg creatinine, urinary a,-microglobulin : 120.5 mgl g creatinine, urinary A-microglobulin : 183.8 pg/ g creatinine, and 24 hours urinary creatinine clearance was 31.9 nd/min. The ultrasonoguided renal biopsy showed the global sclerosis of glomerulus, moderate atrophy and loss of tubule, and interstitial fibrosis in light microscopy.
There were diffuse losses of brush border of proximal tubule in electr~mninicroscopy.
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KEYWORD
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Lead nephropathy, Chronic lead poisoning, Renal biopsy
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